there are 2 possible reasons
1 : it is the game's issue , they did something to block macro mouse type 3rd program
2 : it is your own software issue
to find out down load mouse emulator here
Mouse Emulator - Emulate your mouse with a keyboard
this program is free and clean , no virus i have been using it lately you can scan it if u want
run the mousemu , log in to the game and try pressing NUMPAD 1 or 2 , 1 stands for left click while 2 was assigned to right click , if it works then it is software issue , you can check the config again
if the mousemu doesnt work that means the game has some kinds of anti mouse macro type , i played many games with this include offline games !